Being active is difficult With joint, knee and Back pain
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Simple & 100% natural composition
ReJoint™ is comprised of 5 very carefully sourced, extracted, and balanced herbs-hence its unusually remarkable effectiveness.
Boswellia serrata standardized extract
No fewer than three double-blind, placebo-controlled clinical studies have found that the Ayurvedic herb Boswellia Serrata effectively reduces relapsing and remitting pain and supports healthy joint function and flexibility.1, 2, 3To ensure consistent activity, the boswellia featured in ReJoint™ is standardized to contain a minimum of 70% total organic acids and AKBA – the active constituents.
Horsetail leaf powder
One of the oldest living plants, horsetail has been valued for centuries for its natural stores of minerals. It contains the mineral silica, which is good for building bones and tissues. A recent controlled clinical trial of 60 adults experiencing transient pain found that horsetail had a total effective rate of 80%, compared to just 16.67% for control.4
Nettle leaf powder
Use fresh stinging nettle leaves is an ancient practice for alleviating occasional pain, and an open-label clinical trial indicates it is effective, providing relief as profound as a popular . synthetic remedy.5
Odorless garlic bulb powder
Garlic contains diallyl disulphide, a compound that blocks an enzyme that degrades the extracellular matrix in joint cartilage. (Boswellia has the same action.) A controlled clinical trial found that garlic supplements achieved either a good or partial response in 86.5% of people experiencing pain that comes and goes.6
Celery seed powder
A recent animal study found that celery seed supports healthy levels of uric acid, thus supporting joint comfort. In fact, it was the most effective of all plant extracts tested in this regard.7One of the oldest living plants, horsetail has been valued for centuries for its natural stores of minerals. It contains the mineral silica, which is good for building bones and tissues. A recent controlled clinical trial of 60 adults experiencing transient pain found that horsetail had a total effective rate of 80%, compared to just 16.67% for control.4
Mechanism of Anti-Inflammatory Action
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Boswellia Serrata
- Inhibits TNF-alpha-induced inflammatory response
- Inhibit enzymes (MMP) which catalyze connective tissue breakdown
- Acetyl-11-keto-beta-boswellic acid (AKBA) inhibits NF-kappaB which activates many genes involved in inflammatory responses.
- Inhibits the formation and release of certain inflammatory leukotrienes.
- Inhibits conversion of arachidonic acid to inflammatory leukotrienes.
- Reduces complement activity, known to trigger inflammatory mediators.
- Prevents the breakdown of connective tissue in inflammatory arthritic conditions by reducing glycosaminoglycan (GAG) degradation.
- Reduces enzymes that are elevated in inflammatory conditions like arthritis (such as glutamic pyruvic transaminase, glycohydrolase, and beta-glucuronidase).
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Horsetail
- Horsetail possesses weak diuretic properties, and therefore reduces the swelling of inflamed tissues, thereby reducing pressure on adjacent nerves.
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Stinging Nettle
- Potently suppresses human leukocyte elastase (HLE), one of the most destructive enzymes released by certain white blood cells during the inflammatory process.
- Inhibits TNF-alpha, NF-Kappa B, Leukotiene and Prostaglandin synthesis.
- Lowers levels of interleukin-6 and high-sensitivity C-reactive protein (hs-CRP).
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Celery
- Inhibits mRNA expression of COX-2 in inflammatory responses.
- Suppresses inflammatory mediator release by blocking nuclear factor (NF)-kappaB activation pathways.
- Reduces LPS-induced interleukin (IL)-6 production in the brain.
- Celery possesses weak diuretic properties, and reduces iNOS, an inflammatory mediator.
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Garlic
- Enhances phagocytosis, white blood cell production, natural killer cell activity and prevents immune suppression.
*Above based on Natural Standard database, and a review by Clarke and Mullin, which investigated the immunomodulatory effects of various alternative and complementary therapies, including Boswellia, and the variety of mechanisms by which they disrupt the pro-inflammatory cascade.